Polynucleotide Treatments

What are polynucleotides?

DNA and RNA are two examples of polynucleotides. The polynucleotides used in cosmetic medicine to remodel the skin are made up of highly purified fragments of DNA extracted from wild salmon or trout sperm. The trout used are the same as used for food. Salmon and trout sperm DNA closely resembles human DNA.

Is it safe?

The polynucleotides are highly purified and then sterilised from a licensed source, the production is regulated and the manufacture meets required CE standards of safety. All the protein molecules are removed, so there is no risk of allergy. The science is evidenced based and there are multiple published scientific papers demonstrating safety and efficacy in medicine for the treatment of tissue injury and also in aesthetic medicine. There are no known risks associated with the injection of exogenous (Non-self) polynucleotides. Your clinician will explain the temporary side-effects you may experience.

What can they treat?

● Dull skin

● Course skin

● Wrinkles

● Uneven Pigmentation

● Redness

● Dark circles

● Acne scarring

● Stretch marks

● Surgical scarring

● Hair loss

● Intimate ares - dryness, itching, dehydration, loss of volume

● Not just for the face; hands, neck, chest, arms, knees. Any skin, anywhere on the

body.

How do they work?

Polynucleotides stimulate a receptor on cells which positively influences the following

● Cell proliferation and regeneration

● The repair and regenerative actions of fibroblast cells

● The production of collagen and elastin

● The production of hyaluronic acid

● The production of healthy new micro-blood vessels

● The function of melanocytes which produce pigment.

● They reduce inflammation

● Regulate water balance

● Regulate the formation of fat cells

● Regenerate hair follicles

The use of polynucleotides in regenerative medicine is well established in tissue repair, following traumatic injury or surgery.

What does treatment involve?

The polynucleotides are distilled into a range of strengths and suspended in water for injection. They are injected into the superficial layer of the skin. The clinician uses either a fine needle or a cannula to administer multiple micro-doses into the target area.

A course of three or four treatments 3 to 4 weeks apart is recommended to achieve optimum results.

What results can I expect?

The results are not instant but improvement can be noted from about three weeks and continues to improve over a twelve week period. Patients report a general improvement in the skin which should feel smoother and better hydrated, the texture can be improved. Fine lines and wrinkles are improved. Scarring can be improved, with less depth, smaller and better colour. When hair loss is the concern being addressed, new hair growth can be noted and existing hair will be healthier.

When you use the polynucleotides on the intimate areas, you can experience more hydration, less dryness, and a reduction of itchiness.

Results will vary between individuals as the outcome is dependent upon the biological response of the individual and also lifestyle factors.

How long do results last?

Longevity does vary between individuals. Polynucleotides do not arrest the ageing process, therefore a maintenance treatment is recommended every six months. Life-style factors can effect longevity. If you choose not to maintain the results with further treatment, your skin will return to its pre-treatment state over time.

Scheduling

Because bruising and swelling can occur and may take time to settle, it is not advisable to have treatment just before an important event. Although the majority of patients suffer only minor side effects related to the injections, it is best to allow sufficient time for any possible side effects to resolve. For 12-24 hours you may have visible bumps in the skin. Pin prick marks/scabs may take 5 days to resolve. Bruising can take up to 2 weeks to resolve. Though make-up can be worn the next day. Your clinician will advise. Do not schedule treatment when you have other procedures or medical treatments planned, without first discussing with your clinician. This includes, but is not limited to; vaccinations, massage, facials, dental appointments and surgery.

It is best not to schedule treatment just before a holiday in the sun. Discuss with your clinician.

Am I suitable for treatment?

The clinician will take a detailed medical history to ensure you have no conditions that might increase risk of unwanted side effects, consultation is also important to discuss your expectations and whether this treatment is able to meet them.

Does it hurt?

Treatment can be uncomfortable.

A topical anaesthetic cream will be applied before treatment to numb the skin.

How to prepare for treatment?

Do read all the information provided to you and highlight anything you need to ask about. Check the clinic terms and conditions before attending.

Make-up

All make-up will need to be removed prior to treatment, so please come ‘fresh faced’ if possible.

Check medicines and supplements

Aspirin, Ibuprofen and a range of dietary supplements including St. John’s Wort, fish oils, Ginkgo Biloba, Vitamins C and E- may all contribute to bruising and are best avoided 24 hours before treatment.

Alcohol

Don’t drink alcohol the night before, it will increase your risk of bruising.

Healthy skin and feeling well?

Check with the clinic before attending if any of the following apply

● Cold sores brewing, active or recent or not quite healed.

● Acne break-out

● Feeling unwell- including colds, coughs, sore throats etc.

● New diagnosis or medicines

● New injury for which you are taking pain medicines

● Appointments with the dentist; recent, or planned within 10 days of the treatment

● Travel plans within 10 days of the treatment.